[Hormones and Osteoporosis UPDATE. Calcitonin, CGRP and bone.] Clinical calcium [Clin Calcium] Journal article | | Title | [Hormones and Osteoporosis UPDATE. Calcitonin, CGRP and bone.] | | Author(s) | Ozono K | | Institution | Department of Pediatrics, Osaka University Graduate School of Medicine. | | Source | Clin Calcium 2009 Jul; 19(7):929-34. | | Abstract | Calcitonin is the hormone secreted from parafollicular cells in the thyroid and inhibits osteoclast activity, leading to reduced bone resorption and low levels of serum calcium. Calcitonin is approved to use for osteoporosis and hypercalcemia. However, its effect on the prevention of bone fracture is still controversial, although bone mineral content is apparently improved. The same gene, CALCA, encodes another active peptide, calcitonin gene related peptide (CGRP). CGRP has been reported to promote bone formation based on the high bone mass phenotype of CALCA - deficient mouse. | | Language | jpn | | Pub Type(s) | English Abstract
Journal Article
| | PubMed ID | 19567987 |
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